Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Anubav Vasudevan characterized van Fraassen’s “Infomin” solution to the Judy Benjamin Problem (i.e. the solution by way of minimizing the Kullback-Leibler divergence between the posterior and prior) as an implementation of a “brand of epistemic charity” taking “the form of an assumption on the part of Judy Benjamin that her informant’s evidential report leaves out no relevant information”. After an analysis of the example that led Vasudevan to this way of thinking about Infomin, as well as of a new (...) one that supports the rival position of Douven and Romeijn in favor of minimizing the inverse Kullback-Leibler divergence between the posterior and the prior, we come to a different and more enlightening characterization of Infomin’s implicit assumptions. (shrink)

Global security cannot be achieved until people view the world as a global community. Until such time, differences will continue to be perceived as threatening. These perceived “threats” are the primary threat to global security. This volume proposes methods for minimizing the “us versus them” mentality so that we can build a sense of global community.

The various efforts to put the idea of humanity on a secure ethical, political, and social base have not succeeded. The various post-humanist and transhumanist programs are inadequate. Our deep-seated suspicion of our deepest selves and motives is understandable in light of the barbarity of the twentieth century, but humanism is not to blame. The thought of Ernst Cassirer holds a framework for a new humanism, once it is rid of certain colonialist, triumphalist, and Eurocentric ideas that distorted Cassirer’s understanding (...) of the European role in creating the problems of civilization, especially its mistake of thinking that science was a progressive symbolic form of culture. I set out the basis of a new humanism based upon not the problem of knowledge, but the problem of genuine self-situating socialty, a personalist point of view. (shrink)

Preview: Bergson noted that the cinematographic image does not really move. It is, then as now, a series of still photographs. The real motion in such images is produced by machinery, which imparts a kinesis, an energy of movement, to the succession of fixed images. Our perception then endows such images with their “life,” insofar as they can be said to possess life. It is an illusion, it is “virtual” both as space and time. The real duration, as generated by (...) the machinery or as lived by the perceiver is part of a broader system of images that includes those still photographs and their succession. Images of images of images, by the time they are processed by our bodies and appear to our mind’s eye as inhibited acts we have not enacted. (shrink)

The edited collection Rorty and Beyond assesses and moves beyond Rorty’s legacy, bringing together leading international philosophers. The collection covers diverse territory, from his views about what we may hope for to his personal character, and everything in between.

This paper aims to consider Peirce and Eco’s approach to signs and semiotics in order to assess their relation to Peirce’s mature pragmatism. Both thinkers attempted to set out a truly general theory of signs, and ran into difficulties on similar points. I show that the responses of Peirce and Eco to the difficulties that arose in seeking a truly general theory of signs were quite different. And yet, the differences are not so deep as to prevent us from thinking (...) of both Peirce and Eco as pragmatists, and perhaps of a similar stripe. (shrink)

At the centenary of Frank H. Knight’s Risk, Uncertainty, and Profit, we explore the continuing relevance of Knightian uncertainty to the theory and practice of entrepreneurship. There are three challenges facing such assessment. First, RUP is complex and difficult to interpret. The key but neglected element of RUP is that Knight’s account is not solely about risk and uncertainty as states of nature, but about how an agent’s beliefs about uncertain outcomes and confidence in those beliefs guide their choices. Second, (...) RUP is Knight’s only effort in this area. His subsequent career led elsewhere, so he did not engage with subsequent interpretations of this work. Third, much of the current literature emphasizes that decisions must be different under the two states of nature with a consequent misunderstanding of entrepreneurial agency. This paper addresses each challenge in sequence. First, we explicate Knight’s approach and explain why that approach is murky. Second, as a complement to Knight’s interpretation, we examine Frank P. Ramsey’s approach to subjective probabilities to help clarify Knight’s murky approach. What links Knight and Ramsey is a shared pragmatism about entrepreneurial agency under uncertainty that depends upon the beliefs about, and confidence in, their judgments of possible outcomes. This Knight-Ramsey approach does not require actor’s behaviors to be determined by the class of uncertain environment they face. We focus on the response by the entrepreneur to the existence of uncertainty in all its forms. We argue that this reductive account provides a foundation to examine common problems in management, including managerial hubris, the interaction between entrepreneurs and venture capitalists, and the need for experimentation in advance of new product and venture launches. Third, we critique current literature that favors epistemic purism about the ontology of risk and uncertainty and ignores Knight-Ramsey pragmatism in meeting uncertainty, such as using formal and informal institutions for uncertainty mitigation. Our account locates Frank Knight’s subtleties in entrepreneurial behavior firmly in the literature on entrepreneurial agency a century later. (shrink)

In 1922 Charles Hartshorne, then an aspiring young philosopher, wrote to Edgar Sheffield Brightman, a preeminent philosopher of religion for twenty-three subsequent years and, remarkably, almost every letter was preserved. In their introductory essays, editors Randall Auxier and Mark Davies place the unusually rich and intensive correspondence in its intellectual context and address the relationship between personalism and process philosophy/theology in metaphysics, epistemology, ethics, and social philosophy.

Usually philosophers worry about the existence of mind, or consciousness, or persons, or other difficult-to-explain phenomena. Having posited matter or nature, or fields, they wonder where can person or consciousness originate? This kind of thinking is backward. Only persons ask such questions. Persons exist. I turn the tables on the traditional problem of person by asking whether anything impersonal really exists. I argue that the impersonal almost exists, using the theory of feeling of Max Scheler and supplementing it with insights (...) from Alfred North Whitehead and Josiah Royce. Even though feeling almost succeeds in divesting itself of the pre-supposed act of the person, but its concrete actuality blocks such complete self-abstraction. (shrink)

In the first of two essays on the ontological ground of otherness, and its phenomenological availability, we argue that what we call the “occasion” within the encounter of others are sources as well as re-sources for disclosing the results of a construction and concealment of a secret identity, one we keep from ourselves even though we have created it. Yet, individuals are capable of returning their encounters to the well of sensus communis, and that sensus communis is as natural as (...) it is cultural. Human beings are not compelled to interpret strangeness as threat, even if we are culturally compelled to interpret strangeness itself. Narrative lives in our sensus communis, and it is open, revisable, even danceable. Immediacy is person, the person that is community, and it is sublime, is both liked and disliked. (shrink)

George Holmes Howison’s 1895 essay entitled “The Limits of Evolution,” argued that there are four things evolutionary theory does not explain. In examining whether 11 decades have made a difference in these four, I argue that the arrogance of scientists over the past century in refusing to distinguish between full explanations and explanatory hypotheses is in some ways responsible for the fundamentalist backlash against evolutionary science. A scientific community that is honest and forthcoming about its limitations is to be sought. (...) The best response to Intelligent Design, Creation Science, and other current trends in pseudoscience is to be very clear about the limits of evolutionary theory and the scope of scientific explanation. (shrink)

A clear understanding of social justice requires complex rather than simple answers. It requires comfort with ambiguity rather than absolute answers. This is counter to viewing right versus wrong, just vs. unjust, or good vs. evil as dichotomies. This book provides many examples of where and how to begin to view these as continuums rather than dichotomies.

2 Enoch 58–59 provides an esoteric and somewhat eccentric delineation of attitudes toward the mistreatment of animals within some sect of Egyptian Judaism, in all probability. Three attitudes, having to do with the mistreatment of animals in failing to feed them properly, the wrongful binding of animals for sacrifice, and possible secret sexual exploitation of animals, are delineated along with warnings regarding the effects of such treatment on the human soul at the great judgment. This linking of how humans treat (...) animals with how humans will be judged in “the great age” is unique in the literature of this period and demonstrates a deep concern for animal welfare that has been largely dormant in many facets of religion until more recent times. (shrink)

BOOK REVIEWS 3~3 reaction to them into account. The actual historical dialectic involving Moore, Mal- colm, and Wittgenstein is a good deal more complicated, and more interesting, than the story told here by Stroll. Moving on to Stroll's discussion of Wittgenstein, I should now acknowledge that, so far as I can judge, Stroll offers a largely reliable account of On Certainty. In particular, in the best chapter of the book, on "Wittgenstein's Foundationalism," he makes a convincing case for the view (...) that Wittgenstein, unlike Moore, separates propositional knowledge from the kind of "non-propositional" certainty concerning what "stands fast" for us and which is primarily evinced in our ways of acting. What is less clear to me is just what kind of response to sceptical arguments this amounts to: Stroll says that although at some points Wittgenstein is prepared to countenance, in a relativist spirit which closely adjoins scepticism, radical changes in what is thus cer- tain, by and large towards the end of On Certainty Wittgenstein advances an "absolut- ist" position which rules out such changes. But if this is so , we surely need some arguments why it has to be so. But much here depends on the broader context within which Wittgenstein's position is developed and discussed. Despite noting Wittgenstein's invocation of the conception of man as a "primitive.. (shrink)

Eco says that which cannot be theorized must be narrated. What about that which cannot be narrated? What must we do about the limits of interpretation, especially as narration. This review essay takes a method from Giambattista Vico and applies it to the interpretation of Laurent Binet’s portrayal of Umberto Eco in his novel The Seventh Function of Language. Comparing the character of Eco with the thought of the historical Eco we find coincidences and other angles at incidence that reveal (...) some portion of Binet’s underlying interpretation of Eco, and it limits. (shrink)

Beginning with the present number of The Pluralist, we commence an association with the well known and widely respected Society for the Advancement of American Philosophy, founded in 1972. It is a pleasant circumstance that we can combine our twenty-five-year history of service to pluralistic and personalist philosophies with the admirable mission of the SAAP, which has always stood for openness and responsible philosophical growth with an eye to the lessons of the past and an orientation to a more ideal (...) future for the natural world, its inhabitants, and the role of thought in guiding and evaluating our common direction.Our journal will publish the best and most representative offerings at the annual meeting of .. (shrink)

Aleksandr Dugin is sometimes called “Putin’s brain,” and there can be no question that Putin’s global strategy for expanding Russian power has followed quite precisely a strategic plan created, published, and advocated by Dugin beginning in 1996. This aggressive plan of political destabilization, economic hostage-taking, and ultimately militaristic invasions has been defended with a philosophical patchwork called “the Fourth Political Theory.” Dugin claims his “National Bolshevism” can stand alongside communism, fascism, and liberalism as a genuine contender in ontology, the philosophy (...) of history, and political philosophy; and that it is the only theory that stands in genuine opposition to neo-liberalism and corporate capitalism. I show that this view, built from a distortion of Heidegger’s idea of “human-being” as Dasein, is not a coherent philosophy or worldview. I contrast it with personalism, which has always opposed the very aspects of communism, fascism, and liberalism that Dugin opposes, and does so quite effectively and without militarism, expansionism, or the need to take the nation state as some final end of human political development. (shrink)

The question of the import and role of Christian allusions in Hegel’s Phenomenology of Spirit has received much historical attention, and this continues into the present. Often juxtaposed in this interpretive issue are two questions: Does Hegel think that “the ontological project was first a Greek event from which Christianity would have developed an outer graft”? Or is it more accurate to say that, “for Hegel at least, no ontology is possible before the Gospel or outside it”? In the latter (...) case, Hegel might well place the Greeks precisely where Dante had - in the First Circle of Hell. Those who would make Hegel first a philosopher in the Socratic line tend to emphasize his early work. Those who would make Hegel first a Christian tend to emphasize the later work. This question is too broad to find adequate discussion in the present essay. (shrink)